Muscle Physiology General Overview
The muscle physiology laboratory is dedicated to the education and training of students via scientific research.
Our scientific goal is to understand the design and plasticity of the neuromuscular system.
The UCSD muscle physiology laboratory, located in the Veterans Administration Medical Center, was dedicated on September 16, 1986. Currently, the laboratory is supported by grants from the National Institutes of Health, the Veterans Administration, and private corporations.
The laboratory consists of physiologists, hand surgeons, residents, graduate students, and undergraduates. We encourage collaboration with faculty and scholars from other Universities.
- To discover the underlying design principles of the neuromuscular physiology system.
- To describe and understand the adaptive ability of the neuromuscular system.
- To effectively communicate these findings to the scientific and medical communities.
- To teach the scientific method to high school, undergraduate, graduate, medical and post-doctoral students.
- To develop student's critical thinking ability.
- To provide career guidance at many levels via exposure, discussion and debate.
All of our studies fall into one of two general categories:
Currently, the objectives of the laboratory are:
- To understand the relationship between sarcomere length and joint angle in amphibian and mammalian systems.
- To understand the architectural design of human arm muscles commonly used in surgical tendon transfer procedures.
- To develop analytic and graphical models of muscles, tendons, and the joints on which they act.
- To identify the factors which affect strength recovery in humans following surgical tendon transfer.
- To identify the cellular events associated with muscle adaptation to surgical manipulation.
- To understand the physiological relevance of the various myosin isoforms.
An index of a few abstracts and papers from this year formatted for presentation on the WWW. A more comprehensive list can be found in our Lab Bibliography.
- Intrinsic hand muscle function, part 2: kinematic comparison of 2 reconstructive procedures. Muzykewicz DA, Arnet U, Lieber RL, Fridén J.
- Intrinsic Hand Muscle Function, Part 1: Creating a Functional Grasp. Arnet U, Muzykewicz DA, Fridén J, Lieber RL.
- Comparison of rotator cuff muscle architecture among humans and selected vertebrate species. Mathewson MA, Kwan A, Eng CM, Lieber RL, Ward SR.
- The nebulin SH3 domain is dispensable for normal skeletal muscle structure but is required for effective active load bearing in mouse. Yamamoto DL, Vitiello C, Zhang J, Gokhin DS, Castaldi A, Coulis G, Piaser F, Filomena MC, Eggenhuizen PJ, Kunderfranco P, Camerini S, Takano K, Endo T, Crescenzi M, Luther P, Lieber RL, Chen J, Bang ML.
- Systematic test of neurotoxin dose and volume on muscle function in a rat model. Hulst JB, Minamoto VB, Lim MB, Bremner SN, Ward SR, Lieber RL.
- Loss of FHL1 induces an age-dependent skeletal muscle myopathy associated with myofibrillar and intermyofibrillar disorganization in mice. Domenighetti AA, Chu PH, Wu T, Sheikh F, Gokhin DS, Guo LT, Cui Z, Peter AK, Christodoulou DC, Parfenov MG, Gorham JM, Li DY, Banerjee I, Lai X, Witzmann FA, Seidman CE, Seidman JG, Gomes AV, Shelton GD, Lieber RL, Chen J.
- Architectural design of the pelvic floor is consistent with muscle functional subspecialization. Tuttle LJ, Nguyen OT, Cook MS, Alperin M, Shah SB, Ward SR, Lieber RL.
- The contribution of denervated muscle to contractures following neonatal brachial plexus injury: Not just muscle fibrosis. Nikolaou S, Hu L, Tuttle LJ, Weekley H, Wylie C, Lieber RL, Cornwall R.
- Nerve strain correlates with structural changes quantified by fourier analysis. Love JM, Chuang TH, Lieber RL, Shah SB.
- Cellular Mechanisms of Tissue Fibrosis. 4. Structural and functional consequences of skeletal muscle fibrosis. Lieber RL, Ward SR.
- Functional consequence of distal brachioradialis tendon release: A biomechanical study. Tirrell TF, Franko OI, Bhola S, Hentzen ER, Abrams RA, Lieber RL.
- Role of the cytoskeleton in muscle transcriptional responses to altered use. Meyer GA, Schenk S, Lieber RL.
- Reduced satellite cell population may lead to contractures in children with cerebral palsy. Smith LR, Chambers HG, Lieber RL.
- Systems analysis of biological networks in skeletal muscle function. Smith LR, Meyer G, Lieber RL.
- The skeletal muscle physiology laboratory is supported by the Veterans Administration, the National Institutes of Health, NASA and Preferred Medical Products.
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