Muscle Physiology General Overview
The muscle physiology laboratory is dedicated to the education and training of students via scientific research.
Our scientific goal is to understand the design and plasticity of the neuromuscular system.
The UCSD muscle physiology laboratory, located in the Veterans Administration Medical Center, was dedicated on September 16, 1986. Currently, the laboratory is supported by grants from the National Institutes of Health, the Veterans Administration, and private corporations.
The laboratory consists of physiologists, hand surgeons, residents, graduate students, and undergraduates. We encourage collaboration with faculty and scholars from other Universities.
- To discover the underlying design principles of the neuromuscular physiology system.
- To describe and understand the adaptive ability of the neuromuscular system.
- To effectively communicate these findings to the scientific and medical communities.
- To teach the scientific method to high school, undergraduate, graduate, medical and post-doctoral students.
- To develop student's critical thinking ability.
- To provide career guidance at many levels via exposure, discussion and debate.
All of our studies fall into one of two general categories:
Currently, the objectives of the laboratory are:
- To understand the relationship between sarcomere length and joint angle in amphibian and mammalian systems.
- To understand the architectural design of human arm muscles commonly used in surgical tendon transfer procedures.
- To develop analytic and graphical models of muscles, tendons, and the joints on which they act.
- To identify the factors which affect strength recovery in humans following surgical tendon transfer.
- To identify the cellular events associated with muscle adaptation to surgical manipulation.
- To understand the physiological relevance of the various myosin isoforms.
An index of a few abstracts and papers from this year formatted for presentation on the WWW. A more comprehensive list can be found in our Lab Bibliography.
- Reduced satellite cell number in situ in muscular contractures from children with cerebral palsy. Dayanidhi S, Dykstra PB, Lyubasyuk V, McKay BR, Chambers HG, Lieber RL.
- Dramatic changes in muscle contractile and structural properties after two botulinum toxin injections. Minamoto VB, Suzuki KP, Bremner SN, Lieber RL, Ward SR.
- Collagen crosslinking does not dictate stiffness in a transgenic mouse model of skeletal muscle fibrosis. Chapman MA, Pichika R, Lieber RL.
- Pathophysiology of muscle contractures in cerebral palsy. Mathewson MA, Lieber RL.
- The effect of intrinsic loading and reconstruction upon grip capacity and finger extension kinematics. Muzykewicz DA, Arnet U, Fridén J, Lieber RL.
- Polarization gating enables sarcomere length measurements by laser diffraction in fibrotic muscle. Young KW, Dayanidhi S, Lieber RL.
- Resonant reflection spectroscopy of biomolecular arrays in muscle. Young KW, Radic S, Myslivets E, O'Connor SM, Lieber RL.
- Muscle intermediate filaments form a stress-transmitting and stress- signaling network in muscle. Palmisano MG, Bremner SN, Hornberger TA, Meyer GA, Domenighetti AA, Shah SB, Kiss B, Kellermayer M, Ryan AF, Lieber RL.
- Effect of supraspinatus tendon injury on supraspinatus and infraspinatus muscle passive tension and associated biochemistry. Silldorff MD, Choo AD, Choi AJ, Lin E, Carr JA, Lieber RL, Lane JG, Ward SR.
- Three-dimensional reconstruction of skeletal muscle extracellular matrix ultrastructure. Gillies AR, Bushong EA, Deerinck TJ, Ellisman MH, Lieber RL.
- High resolution muscle measurements provide insights into equinus contractures in patients with cerebral palsy. Mathewson MA, Ward SR, Chambers HG, Lieber RL.
- The skeletal muscle physiology laboratory is supported by the Veterans Administration, the National Institutes of Health, NASA and Preferred Medical Products.
Last Updated: Wednesday, 13-Jul-2016 15:18:12 PDT
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