Excitation Contraction Coupling
Like most excitable cells, muscle fibers respond to the excitation signal with a rapid depolarization which is coupled with its physiological response: contraction.
Cellular Resting Potential
If we remember that myofibers are basically water with some dissolved ions separated from the extracellular space, which is also mostly water with some dissolved ions, then the presence of a resting potential may make more sense. In much the same way as a battery creates an electrical potential difference by having different concentrations of ions at its two poles, so does a muscle cell generate a potential difference across its cell membrane. The ATP driven sodium-potassium pump maintains an artificially low concentration of sodium and high concentration of potassium in the intracellular space, which generates a resting potential difference on the order of -75 mV.
Depolarization is achieved by other transmembrane channel proteins. When the potential difference near these voltage sensitive proteins reaches a threshold level, the protein undergoes a magical conformational change that makes the membrane permeable to sodium. Extracellular sodium immediately rushes in, drawn by both the charge difference and concentration gradient, and locally depolarizes the cell. Almost immediately, potassium also moves along in concentration gradient - out of the cell -- and the membrane potential is restored.
As an interesting side note, this is the mechanism by which potassium chloride is used to induce cardiac arrest: by eliminating the potassium concentration gradient, the depolarized cardiac muscle cells are unable to repolarize for their next beat.
Last Updated: Friday, 13-Jan-2006 15:56:14 PST
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